Serotonin syndrome occurs when drug interactions or overdose causes serotonin levels to rise to potentially dangerous levels. Serotonin syndrome, also referred to as serotonin toxicity, is a potentially life-threatening condition associated with increased serotonergic activity in the c Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA). Linezolid is an antibiotic that fights bacteria in the body. Linezolid is also an MAO (monoamine oxidase) inhibitor. Linezolid is used to treat different types of bacterial infections, such as pneumonia, skin infections, and infections that are resistant to other antibiotics. Health care professionals should discontinue opioid treatment and/or use of the other medicine if serotonin syndrome is suspected. Serotonin syndrome occurs when drug interactions or overdose causes serotonin levels to rise to potentially dangerous levels. Page 3 of 29. 2.5 Use of BRINTELLIX with Other MAOIs such as Linezolid or Methylene Blue. Do not start BRINTELLIX in a patient who is being treated with linezolid or intravenous Although the exact mechanism of this drug interaction is unknown, linezolid inhibits the action of monoamine oxidase A—an enzyme responsible for breaking down serotonin in the brain. 600 mg IV every 12 hours for 10 to 14 days. Clinical practice guidelines recommend linezolid as an empiric therapy option for CAP in ICU patients with suspected MRSA or in any patient with documented MRSA as well as alternative therapy in patients with penicillin-resistant S. pneumoniae. US Pharm. 2010;35(11):HS-16-HS-21. A potentially lethal condition, serotonin syndrome (SS) is caused most often when certain antidepressant agents are taken concurrently with other drugs that modulate synaptic serotonin levels. 1,2 When patients take two or more antidepressants from different pharmacologic classes, drug-drug interactions may.